Hepatic Biomarker Abnormalities in the Cardiac Intensive Care Unit: Proposed Criteria for Cardiohepatic Syndrome.

ABSTRACT:

Background

Liver synthetic dysfunction predicts outcomes in cardiac intensive care unit (CICU) patients.

Objectives

The purpose of this study was to evaluate the associations between the severity and extent of admission liver function test (LFT) abnormalities and mortality in a mixed CICU population.

Methods

This historical cohort study included unique CICU patients from 2007 to 2018 with available data for admission LFT values. We categorized each LFT from grade 0 to grade 4 based on multiples of the upper limit of normal. We evaluated in-hospital mortality using logistic regression and 1-year mortality using Cox proportional hazards regression.

Results

We included 7,284 patients, and 3,477 (47.7%) had at least 1 LFT with grade 1 or greater. In-hospital mortal

SUBMITTER: Butt A 

PROVIDER: S-EPMC11755386 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature