Reducing the Formation of Toxic Byproducts During the Photochemical Release of Epinephrine.

ABSTRACT: Engineered light-sensitive molecules offer a sophisticated toolkit for the manipulation of biological systems with both spatial and temporal precision. Notably, artificial "caged" compounds can activate specific receptors solely in response to light exposure. However, the uncaging process can lead to the formation of potentially harmful byproducts. For example, the photochemical release of adrenaline (epinephrine) is accompanied by the formation of adrenochrome, which has neuro- and cardiotoxic effects. To investigate this effect in detail, we synthesized and compared two "caged" epinephrine analogs. The first was a classical compound featuring an ortho-nitrobenzyl protecting group attached to the amino group of epinephrine. The second analog retained the ortho-nitrobenzyl gr

SUBMITTER: Panfilov MA 

PROVIDER: S-EPMC11755455 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature