The Issue of "Smart Drugs" on the Example of Modafinil: Toxicological Analysis of Evidences and Biological Samples.

ABSTRACT: Cognitive enhancement through stimulants such as modafinil is becoming increasingly popular, with many individuals using prescription stimulants for non-medical purposes to improve alertness, attention, and mood. The misuse of such substances has raised concerns, particularly in forensic toxicology. The UHPLC-QqQ-MS/MS method was developed to quantify modafinil in evidentiary samples and biological materials. Additionally, the authors noted the presence of sodium adducts during the analysis of samples with high concentrations of modafinil. The method was validated for accuracy, precision, and linearity, with a concentration range of 0.1-10.0 µg/mL for the evidences and 1.0-100.0 ng/mL for blood. The method successfully detected modafinil as the sole substance in all evidences, with concent

SUBMITTER: Nowak K 

PROVIDER: S-EPMC11755661 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature