LncRNA <i>3222401L13Rik</i> Is Upregulated in Aging Astrocytes and Regulates Neuronal Support Function Through Interaction with Npas3.

ABSTRACT: Aging leads to cognitive decline and increased risk of neurodegenerative diseases. While molecular changes in central nervous system (CNS) cells contribute to this decline, the mechanisms are not fully understood. Long non-coding RNAs (lncRNAs) are key regulators of cellular functions. Background/Objectives: The roles of lncRNAs in aging, especially in glial cells, are not well characterized. Methods: We investigated lncRNA expression in non-neuronal cells from aged mice and identified 3222401L13Rik, a previously unstudied lncRNA, as upregulated in astrocytes during aging. Results: Knockdown of 3222401L13Rik in primary astrocytes revealed its critical role in regulating genes for neuronal support and synapse organization, a function conserved in human iPSC-derived astr

SUBMITTER: Schroder S 

PROVIDER: S-EPMC11755665 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature