Interrater reproducibility of the Myoton and durometer devices to quantify sclerotic chronic graft-versus-host disease.

ABSTRACT: Chronic graft-versus-host disease (cGVHD) is a severe complication in long-term survivors of allogeneic hematopoietic stem cell transplantation. This disease is challenging to manage clinically due to a lack of validated tools to quantitatively measure skin sclerosis. The current gold standard for measuring skin sclerosis is the NIH Skin Score which has only moderate agreement among clinicians and experts. To more accurately assess skin sclerosis in cGVHD, the Myoton and durometer devices can be used to directly measure biomechanical parameters of the skin. However, the reproducibility of these devices is not known in patients with cGVHD. To determine this reproducibility, three observers independently measured 10 anatomic sites in each of seven patients with sclerotic cGVHD using the Myot

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC11755669 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature