Influence of Tacticity on the Self-Assembly of Poly(ethylene glycol)-<i>b</i>-poly(lactic acid) Block Copolymers.

ABSTRACT: Lactide, possessing two stereocenters and thus three distinct configurations (DD, DL, and LL), serves as a captivating building block for polymers and self-assembly. Notably, polylactide (PLA) exhibits stereocomplexation, displaying heightened interactions between different configurations compared with interactions within the same configuration. This characteristic renders PLA an intriguing subject for investigating self-assembly behavior. In this study, 22 PEG-b-PLA polymers were synthesized and self-assembled, with analysis conducted through NMR and cryo-TEM techniques. A range of morphologies, including vesicles, diamond-shaped lamellae, and branched networks, were achieved by manipulating the tacticities. Enhanced comprehension of self-assembly interactions holds promise for adv

SUBMITTER: Rijpkema SJ 

PROVIDER: S-EPMC11755779 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature