Dysregulation of transposable elements and PIWI-interacting RNAs in myelodysplastic neoplasms.

ABSTRACT:

Background

Myelodysplastic neoplasms (MDS) are heterogeneous hematopoietic disorders characterized by ineffective hematopoiesis and genome instability. Mobilization of transposable elements (TEs) is an important source of genome instability leading to oncogenesis, whereas small PIWI-interacting RNAs (piRNAs) act as cellular suppressors of TEs. However, the roles of TEs and piRNAs in MDS remain unclear.

Methods

In this study, we examined TE and piRNA expression through parallel RNA and small RNA sequencing of CD34+ hematopoietic stem cells from MDS patients.

Results

Comparative analysis of TE and piRNA expression between MDS and control samples revealed several significantly dysregulated molecules. However, significant differences were observed between lower-risk MDS (

SUBMITTER: Krejcik Z 

PROVIDER: S-EPMC11755807 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature