Epigenome-wide association study of objectively measured physical activity in peripheral blood leukocytes.

ABSTRACT:

Background

Few studies have explored the association between DNA methylation and physical activity. The aim of this study was to evaluate the association of objectively measured hours of sedentary behavior (SB) and moderate physical activity (MPA) with DNA methylation. We further aimed to explore the association between SB or MPA related CpG sites and cardiometabolic traits, gene expression, and genetic variation.

Results

For discovery, we performed cross sectional analyses in pregnant women from the Epigenetics in pregnancy (EPIPREG) sample with both DNA methylation (Illumina MethylationEPIC BeadChip) and objectively measured physical activity data (SenseWear™ Pro 3 armband) (European = 244, South Asian = 109). For EWAS of SB and MPA, two main models were designed: model (1

SUBMITTER: Fragoso-Bargas N 

PROVIDER: S-EPMC11755845 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature