Histopathology of the tongue in a hamster model of COVID-19.

ABSTRACT:

Objective

With altered sense of taste being a common symptom of coronavirus disease 2019 (COVID-19), the main objective was to investigate the presence and distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) within the tongue over the course of infection.

Methods

Golden Syrian hamsters were inoculated intranasally with SARS-CoV-2 and tongues were collected at 2, 3, 5, 8, 17, 21, 35, and 42 days post-infection (dpi) for analysis. In order to test for gross changes in the tongue, the papillae of the tongue were counted. Paraffin-embedded thin sections of the tongues were labeled for the presence of SARS-CoV-2 antigen.

Results

There was no difference in fungiform or filiform papillae density throughout the course of infection. SARS-CoV-2 antigen

SUBMITTER: Coggins J 

PROVIDER: S-EPMC11755867 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature