Evidence for a NOD2-independent susceptibility locus for inflammatory bowel disease on chromosome 16p.

ABSTRACT: Heritable predisposition to inflammatory bowel disease (IBD) has been demonstrated by epidemiological and genetic analysis. Linkage of IBD to broad regions of chromosome 16 has been established by analysis of multiple populations. NOD2, located on proximal 16q, was recently identified as an IBD gene. As the linkage regions on chromosome 16 are large, we have investigated the possibility that NOD2 is not the only IBD gene located on this chromosome. A high-density experiment using 39 microsatellite markers was performed to identify additional regions of association, and to indicate areas of interest for further investigation. A triple-peaked configuration of the linkage curve with peak logarithm of odds (lod) scores of 2.7, 3.2, and 3.1 was observed on proximal 16p, proximal 16q, and centra

SUBMITTER: Hampe J 

PROVIDER: S-EPMC117559 | biostudies-literature | 2002 Jan

REPOSITORIES: biostudies-literature