Mesenchymal stromal cells-derived extracellular vesicles in cartilage regeneration: potential and limitations.

ABSTRACT:

Background

Articular cartilage injuries can lead to pain, stiffness, and reduced mobility, and may eventually progress to osteoarthritis (OA). Despite substantial research efforts, effective therapies capable of regenerating cartilage are still lacking. Mesenchymal stromal cells (MSCs) are known for their differentiation and immunomodulatory capabilities, yet challenges such as limited survival post-injection and inconsistent therapeutic outcomes hinder their clinical application. Recent evidence suggests that the beneficial effects of MSCs are largely mediated by their secreted small extracellular vesicles (sEVs), which have been shown to promote tissue repair and reduce inflammation. MSC-derived sEVs have shown promise in mitigating cartilage degradation and chondrocyte apoptosis

SUBMITTER: Pineiro-Ramil M 

PROVIDER: S-EPMC11755911 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature