Analysis of the correlation between the group-based trajectory modeling of serum osmolality and prognosis in patients with sepsis-associated encephalopathy at 72 h after admission.

ABSTRACT:

Background

This study aimed to identify distinct trajectories of serum osmolality within the first 72 h for patients with sepsis-associated encephalopathy (SAE) in the MIMIC-IV and eICU-CRD databases and assess their impact on mortality and adverse clinical outcomes.

Methods

In this retrospective cohort study, patients with SAE from the MIMIC-IV database were included. Group-based trajectory modeling (GBTM) was used to categorize distinct patterns of serum osmolality changes over 72 h in ICU patients. Differences in survival across the trajectory groups were compared using Kaplan-Meier (K-M) survival curves.

Results

A total of 11,376 patients with SAE were included in the analysis, with a median age of 65.6 ± 16.5 years. The in-hospital mortality rate at 30 days was 1

SUBMITTER: Wu W 

PROVIDER: S-EPMC11755937 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature