Evolutionary constrained genes associated with autism spectrum disorder across 2,054 nonhuman primate genomes.

ABSTRACT:

Background

Significant progress has been made in elucidating the genetic underpinnings of Autism Spectrum Disorder (ASD). However, there are still significant gaps in our understanding of the link between genomics, neurobiology and clinical phenotype in scientific discovery. New models are therefore needed to address these gaps. Rhesus macaques (Macaca mulatta) have been extensively used for preclinical neurobiological research because of remarkable similarities to humans across biology and behaviour that cannot be captured by other experimental animals.

Methods

We used the macaque Genotype and Phenotype (mGAP) resource consisting of 2,054 macaque genomes to examine patterns of evolutionary constraint in known human neurodevelopmental genes. Residual variation intolerance sc

SUBMITTER: Kikuchi Y 

PROVIDER: S-EPMC11755938 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature