Extracellular matrix turnover in severe COVID-19 is reduced by corticosteroids.

ABSTRACT:

Background

Severe and critical COVID-19 is characterized by pulmonary viral infection with SARS-CoV-2 resulting in local and systemic inflammation. Dexamethasone (DEX) has been shown to improve outcomes in critically ill patients; however, its effect on tissue remodeling, particularly collagen turnover, remains unclear. This study investigated the association between circulating extracellular matrix (ECM) remodeling neo-epitopes and COVID-19 severity, their relationship with mortality, and the effect of DEX on these markers.

Methods

We conducted a multi-center prospective cohort study involving 226 COVID-19 patients: 157 with severe disease admitted to the ward and 69 with critical disease admitted to the ICU. Plasma samples were collected at ICU admission and at discharge o

SUBMITTER: Pillay J 

PROVIDER: S-EPMC11755962 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature