Fezolinetant's efficacy and safety in treatment of vasomotor symptoms in postmenopausal women: a meta-analysis and GRADE evaluation of randomized controlled trials.

ABSTRACT:

Background

Postmenopausal women are more likely to experience vasomotor symptoms (VMS), such as heat sensation and sweating. Recent trials have investigated fezolinetant in the treatment of VMS in postmenopausal women. Our study aims to conduct a meta-analysis of these trials in order to estimate fezolinetant's effectiveness and safety in the management of VMS in postmenopausal women.

Method

We searched Cochrane, PubMed, Scopus, and Web of Science for all published randomized controlled trials. Review Manager Software was used for the meta-analysis. The quality of evidence was graded using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework.

Results

Our study contained five trials with 3295 individuals with a mean age of 54.4 yea

SUBMITTER: Allam AR 

PROVIDER: S-EPMC11755967 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature