Exosome-loading miR-205: a two-pronged approach to ocular neovascularization therapy.

ABSTRACT: Pathological neovascularization is a hallmark of many vision-threatening diseases. However, some patients exhibit poor responses to current anti-VEGF therapies due to resistance and limited efficacy. Recent studies have highlighted the roles of noncoding RNAs in various biological processes, paving the way for RNA-based therapeutics. In this study, we report a marked down-regulation of miR-205 under pathological conditions. miR-205 potently inhibits endothelial cell functions critical for pathological neovascularization, including proliferation, migration, and tube formation. Furthermore, miR-205 strengthens the endothelial barrier, thereby reducing vascular leakage. In mouse models of retinal and choroidal neovascularization, miR-205 administration effectively suppresses abnormal blood ve

SUBMITTER: Zhang HY 

PROVIDER: S-EPMC11756024 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature