The impact of oxidative balance on all-cause and cause-specific mortality in US adults and cancer survivors: evidence from NHANES 2001-2018.

ABSTRACT:

Background

Oxidative stress is a crucial pathophysiological mechanism in chronic diseases and mortality. While individual oxidative markers have been studied, the comprehensive impact of oxidative balance on mortality risks remains unclear, particularly among cancer survivors. We aimed to investigate the associations of Oxidative Balance Score (OBS) with mortality in both the general population and cancer survivors.

Methods

This study included 37,317 adults (52% female) from the National Health and Nutrition Examination Survey (2001-2018). OBS was calculated based on antioxidant and pro-oxidant exposures and categorized into quartiles. Survey-weighted Cox proportional hazards models were used to estimate hazard ratios for mortality risks. Restricted cubic spline analyses wer

SUBMITTER: Wu J 

PROVIDER: S-EPMC11756090 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature