Neutrophil extracellular traps (NETs) are increased in rheumatoid arthritis-associated interstitial lung disease.

ABSTRACT:

Background

Neutrophil extracellular trap (NET) formation has been implicated as a pathogenic mechanism in both rheumatoid arthritis (RA) and interstitial lung disease (ILD). However, the role of NETs in RA-associated ILD (RA-ILD) and the mechanisms driving NET formation remain unclear. This study aimed to assess the involvement of NETs in RA-ILD and elucidate the underlying mechanisms.

Methods

Single-cell sequencing was used to identify changes in the quantity and function of neutrophils in the lung tissue of a zymosan A (ZYM)-induced interstitial pneumonia arthritis model. Additionally, nuclear receptor 4A3 (NR4A3) interference was performed in HL-60 cells to assess its impact on NET formation and the transformation of MRC-5 cells into myofibroblasts. The clinical relevance

SUBMITTER: Xue J 

PROVIDER: S-EPMC11756115 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature