Promoting epithelial regeneration in chemically induced acute lung injury through Sox9-positive alveolar type 2 epithelial cells.

ABSTRACT:

Background

Chemical-induced acute lung injury is characterized by impaired epithelial regenerative capacity, leading to acute pulmonary edema. Numerous studies have investigated the therapeutic potential of endogenous stem cells with particular emphasis on alveolar type 2 epithelial (AEC2) cells owing to their involvement in lung cell renewal. Sox9, a transcription factor known for its role in maintaining stem cell properties and guiding cell differentiation, marks a subset of AEC2 cells believed to contribute to epithelial repair. However, the role of Sox9⁺AEC2 cells in the distal lung alveolar cells and the potential roles in chemically induced acute lung injury have never been explored.

Methods

In this study, we generated Sox9^flox/flox;Sftpc^Cre-

SUBMITTER: Cao C 

PROVIDER: S-EPMC11756119 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature