MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB.

ABSTRACT:

Background

The senescence of bone marrow mesenchymal stem cells (BMMSCs) is increasingly recognized as a critical factor contributing to the pathophysiology of age-related diseases. Recent studies suggest that small extracellular vesicles (sEVs) derived from the serum of elderly individuals may play a pivotal role in promoting BMMSC senescence. Glycoprotein non-metastatic melanoma protein B (GPNMB), a type I transmembrane glycoprotein, is upregulated during cellular senescence and can regulate stem cell ageing. However, the precise mechanisms by which GPNMB influences BMMSCs senescence remain poorly understood. Understanding this relationship could provide valuable insights into therapeutic strategies for enhancing BMMSCs function and mitigating age-related degeneration.

Methods

SUBMITTER: Ma Y 

PROVIDER: S-EPMC11756183 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature