Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium.

ABSTRACT:

Background

Night shift work during pregnancy has been associated with differential DNA methylation in placental tissue, but no studies have explored this association in cord blood. We aimed to examine associations of maternal night shift work with cord blood DNA methylation.

Methods

A total of 4487 mother-newborn pairs from 7 studies were included. Maternal night shift work during pregnancy was ascertained via questionnaires and harmonized into "any" versus "no". DNA methylation was measured in cord blood using the Illumina Infinium Methylation arrays. Robust linear regression models adjusted for relevant confounders were run in the individual cohorts, and results were meta-analyzed.

Results

Maternal night shift work during pregnancy ranged from 3.4% to 26.3%. Three C

SUBMITTER: Marques IF 

PROVIDER: S-EPMC11756212 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature