Association between white blood cell count and coronary artery bypass graft failure: an individual patient data analysis of clinical trials.

ABSTRACT:

Background

Baseline systemic inflammation is associated with worse long-term outcomes after coronary artery bypass grafting [CABG], but the mechanisms of this association are unclear. This study aims to explore the association between pre-operative white blood cell [WBC] count and CABG graft failure.

Methods

We pooled individual patient data from two randomized clinical trials with systematic CABG graft imaging. The primary analysis was the association between pre-operative WBC count and graft failure, as a continuous variable, at the time of imaging after CABG, using mixed-effects multivariable logistic regression models.

Results

Overall, 910 patients and 2,036 grafts were included in the analysis [1,120 saphenous vein grafts, 828 left internal thoracic arteries, 76

SUBMITTER: An KR 

PROVIDER: S-EPMC11756219 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature