Subtilosin A production is influenced by surfactin levels in <i>Bacillus subtilis</i>.

ABSTRACT: Although not essential for their growth, the production of secondary metabolites increases the fitness of the producing microorganisms in their natural habitat by enhancing establishment, competition, and nutrient acquisition. The Gram-positive soil-dwelling bacterium, Bacillus subtilis, produces a variety of secondary metabolites. Here, we investigated the regulatory relationship between the non-ribosomal peptide surfactin and the sactipeptide bacteriocin subtilosin A. We discovered that B. subtilis mutants lacking surfactin production exhibited higher production of subtilosin A compared to their parental wild-type strain. Additionally, spatial visualization of B. subtilis production of metabolites demonstrated that surfactin secreted by a wild-type colony could suppr

SUBMITTER: Dinesen C 

PROVIDER: S-EPMC11756287 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature