Value and Kinetics of Virological Markers in the Natural Course of Chronic Hepatitis D Virus Infection.

ABSTRACT:

Background and aims

Chronic hepatitis D virus (HDV) infection can cause severe liver disease. With new treatment options available, it is important to identify patients at risk for liver-related complications. We aimed to investigate kinetics and predictive values of novel virological and immunological markers in the natural course of chronic HDV infection.

Methods

HBcrAg, HBV RNA and quantitative anti-HBc were analysed in samples from HDV-infected patients at three consecutive time points. Results were linked to clinical outcome by univariable and multivariable analyses. Primary endpoint was the composite endpoint of any liver-related event.

Results

Samples from 190 individual patients were analysed with a median clinical follow-up time of 2.69 (IQR 1.13-6.51) years.

SUBMITTER: Sandmann L 

PROVIDER: S-EPMC11756344 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature