Genetic determinants of COVID-19 severity and mortality: <i>ACE1</i> Alu 287 bp polymorphism and <i>ACE1</i>, <i>ACE2</i>, <i>TMPRSS2</i> expression in hospitalized patients.

ABSTRACT:

Background

The angiotensin-converting enzyme 2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) are central human molecules in the SARS-CoV-2 virus-host interaction. Evidence indicates that ACE1 may influence ACE2 expression. This study aims to determine whether ACE1, ACE2, and TMPRSS2 mRNA expression levels, along with the ACE1 Alu 287 bp polymorphism (rs4646994), contribute to the severity and mortality of COVID-19.

Methods

Swabs were collected in two Brazilian cities in 2020: Belo Horizonte (n = 134) and Rio de Janeiro (n = 41). A swab of mild patients in Rio de Janeiro who were not hospitalized (n = 172) was also collected. All analyzed biological material was obtained from residual diagnostic samples in 2020, prior to the emerg

SUBMITTER: de Araujo JLF 

PROVIDER: S-EPMC11756369 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature