Synthesis and evaluation of nitrochromene derivatives as potential antileishmanial therapeutics through biological and computational studies.

ABSTRACT: Leishmaniasis is a parasitic disease caused by protozoan organisms belonging to the Leishmania genus, affecting many individuals worldwide, with the burden surpassing one million cases. This disease leads to considerable morbidity and mortality, predominantly within tropical and subtropical regions. The current therapeutic options for leishmaniasis are far from ideal, as they fail to achieve a level of efficacy that can be deemed universally effective. The primary drawbacks of existing treatments include severe side effects, substantial toxicity, high financial costs, extended treatment regimens, and the discomfort associated with injectable forms of administration. Additionally, the growing issue of drug resistance presents a formidable challenge, further complicating disease management a

SUBMITTER: Javid N 

PROVIDER: S-EPMC11756393 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature