Introducing CELLBLOKS^®: a novel organ-on-a-chip platform allowing a plug-and-play approach towards building organotypic models.

ABSTRACT: Human organs are structurally and functionally complex systems. Their function is driven by the interactions between many specialised cell types, which is difficult to unravel on a standard Petri dish format. Conventional "Petri dish" approaches to culturing cells are static and self-limiting. However, current organ-on-a-chip technologies are difficult to use, have a limited throughput and lack compatibility with standard workflow conditions. We developed CELLBLOKS^® as a novel "plug-and-play" organ-on-a-chip platform that enables straightforward creation of multiple cell-type organ-specific microenvironments. Herein, we demonstrate its advantages by building a liver model representative of live tissue function. CELLBLOKS^® allows one to systematically test and identify

SUBMITTER: Llabjani V 

PROVIDER: S-EPMC11756440 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature