Ex vivo models for intestinal translocation studies of cellulose nanocrystals.

ABSTRACT:

Purpose

Cellulose nanocrystals (CNC) play a promising role in the development of new advanced materials. The growing demand of CNC-containing products in the food industry will lead to an increased human exposure through oral uptake. To date, there is a dearth of studies reporting on the risks which CNC pose to human health following ingestion. In vitro models, which lack physiological accuracy, are often used to justify animal experiments in the field of nanosafety assessment. Nevertheless, ex vivo models of the intestine pose promising alternatives to in vivo experiments.

Methods

Two ex vivo models, a microfluidic chip based on porcine intestinal mucus and the Ussing chamber apparatus with tissue from abattoirs, which aim to complement in vitro models, are characterized by

SUBMITTER: Muller M 

PROVIDER: S-EPMC11756450 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature