A human Caco-2-based co-culture model of the inflamed intestinal mucosa for particle toxicity studies.

ABSTRACT: The intestinal barrier is a complex interface of the human body, possessing the largest contact surface to nutrients and antigens and containing a major part of the immune system. It has to deal with continuous exposure to a broad mixture of essential, harmful, or useless substances and particles. In the context of plastic pollution and the ubiquitous occurrence of micro- and nanoplastics, oral exposure to such particles is of particular interest. Standard intestinal in vitro models, however, are unable to mimic the role of the immune system in the particle-exposed intestine. To allow for a closer look on the effect of particles on the intestinal immune system, we here developed a co-culture model to enable investigation of the epithelial brush border monolayer in a healthy and inflamed st

SUBMITTER: Paul MB 

PROVIDER: S-EPMC11756451 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature