Development of a tissue-engineered skin model with epidermal, dermal and hypodermal components.

ABSTRACT: Tissue-engineered models of skin have evolved over the past 50 years, have successfully been translated to clinical use and continue to be improved using new technologies. However, very few of these constructs incorporate a hypodermal component. The hypodermis is critical to skin homeostasis, skin function and many skin diseases, but our understanding of the hypodermis is limited in comparison to our knowledge of the epidermis and dermis, in part due to a lack of suitable in vitro models. The purpose of this study was to develop and characterise a tissue-engineered model of skin consisting of epidermal, dermal and hypodermal layers, namely a trilayer skin model. Models were produced by culturing human keratinocytes and fibroblasts on decellularised human dermis in combination with explante

SUBMITTER: Workman VL 

PROVIDER: S-EPMC11756454 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature