Modelling neurodegeneration and inflammation in early diabetic retinopathy using 3D human retinal organoids.

ABSTRACT:

Purpose

Diabetic retinopathy (DR) is a complication of diabetes and a primary cause of visual impairment amongst working-age individuals. DR is a degenerative condition in which hyperglycaemia results in morphological and functional changes in certain retinal cells. Existing treatments mainly address the advanced stages of the disease, which involve vascular defects or neovascularization. However, it is now known that retinal neurodegeneration and inflammation precede these vascular changes as early events of DR. Therefore, there is a pressing need to develop a reliable human in vitro model that mimics the early stage of DR to identify new therapeutic approaches to prevent and delay its progression.

Methods

Here, we used human-induced pluripotent stem cells (hiPSCs) differen

SUBMITTER: de Lemos L 

PROVIDER: S-EPMC11756505 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature