Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals.

ABSTRACT: Whole blood transcriptome analysis is a valuable approachin medical research, primarily due to the ease of sample collection and the richness of the information obtained. Since the expression profile of individual genes in the analysis is influenced by medical traits and demographic attributes such as age and gender, there has been a growing demand for a comprehensive database for blood transcriptome analysis. Here, we performed whole blood RNA sequencing (RNA-seq) analysis on 576 participants stratified by age (20-30s and 60-70s) and gender from cohorts of the Tohoku Medical Megabank (TMM). A part of female segment included pregnant women. We did not exclude the globin gene family in our RNA-seq study, which enabled us to identify instances of hereditary persistence of fetal hemoglobin ba

SUBMITTER: Aoki YI 

PROVIDER: S-EPMC11756699 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature