Effectiveness of electronic medical record-based strategies for death and hospital admission endpoint capture in pragmatic clinical trials.

ABSTRACT:

Objective

Event capture in clinical trials is resource-intensive, and electronic medical records (EMRs) offer a potential solution. This study develops algorithms for EMR-based death and hospitalization capture and compares them with traditional event capture methods.

Materials and methods

We compared the effectiveness of EMR-based event capture and site-captured events adjudicated by a clinical endpoint committee in the multi-center INfluenza Vaccine to Effectively Stop cardio Thoracic Events and Decompensated heart failure (INVESTED) trial for participants from the Veterans Affairs healthcare system. Varying time windows around event dates were used to optimize events matching. The algorithms were externally validated for heart failure hospitalizations in the Medical Infor

SUBMITTER: Rahafrooz M 

PROVIDER: S-EPMC11756702 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature