Development and validation of a high-throughput qPCR platform for the detection of soil-transmitted helminth infections.

ABSTRACT:

Background

Historically, soil-transmitted helminth (STH) control and prevention strategies have relied on mass drug administration efforts targeting preschool and school-aged children. While these efforts have succeeded in reducing morbidity associated with STH infection, recent modeling efforts have suggested that expanding intervention to treatment of the entire community could achieve transmission interruption in some settings. Testing the feasibility of such an approach requires large-scale clinical trials, such as the DeWorm3 cluster randomized trial. In addition, accurate interpretation of trial outcomes requires diagnostic platforms capable of accurately determining infection prevalence (particularly as infection intensity is reduced) at large population scale and with signi

SUBMITTER: Pilotte N 

PROVIDER: S-EPMC11756772 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature