Pharmacological inhibition of key metabolic pathways attenuates Leishmania spp infection in macrophages.

ABSTRACT: Macrophages represent a fundamental component of the innate immune system that play a critical role in detecting and responding to pathogens as well as danger signals. Leishmania spp. infections lead to a notable alteration in macrophage metabolism, whereby infected cells display heightened energy metabolism that is linked to the integrity of host mitochondria. However, little is known about how different species of Leishmania manipulate host metabolism. Here, we demonstrate that despite differences in their mechanisms for evading host immune responses, L. amazonensis and L. braziliensis induce comparable disruptions in key metabolic pathways. We found that infected macrophages exhibited an overall elevation in energy metabolism regardless of the parasite strain, evidenced by the elevation

SUBMITTER: de Oliveira EC 

PROVIDER: S-EPMC11756801 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature