Single-Cell Multi-Omics Profiling of Immune Cells Isolated from Atherosclerotic Plaques in Male ApoE Knockout Mice Exposed to Arsenic.

ABSTRACT:

Background

Millions worldwide are exposed to elevated levels of arsenic that significantly increase their risk of developing atherosclerosis, a pathology primarily driven by immune cells. While the impact of arsenic on immune cell populations in atherosclerotic plaques has been broadly characterized, cellular heterogeneity is a substantial barrier to in-depth examinations of the cellular dynamics for varying immune cell populations.

Objectives

This study aimed to conduct single-cell multi-omics profiling of atherosclerotic plaques in apolipoprotein E knockout (ApoE^-/-) mice to elucidate transcriptomic and epigenetic changes in immune cells induced by arsenic exposure.

Methods

The ApoE^-/- mice were fed a high-fat diet and were expose

SUBMITTER: Makhani K 

PROVIDER: S-EPMC11756858 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature