Reverse Fragility Index in Plastic Surgery Randomized Controlled Trials.

ABSTRACT:

Background

The reverse fragility index (RFI) is a measure used to evaluate the neutrality of statistically nonsignificant findings in randomized controlled trials (RCTs). The RFI represents the minimum number of events needed to reverse a statistically nonsignificant result into a significant one. This study applied the RFI to examine the robustness of statistically nonsignificant RCTs in plastic surgery.

Methods

A systematic literature search of the 10 highest impact journals covering plastic and reconstructive surgery topics was conducted to identify RCTs published between January 2000 and March 2023. The Fisher exact test was used to calculate the RFI for each primary outcome. Bivariate analysis was performed to investigate the association of trial characteristics with th

SUBMITTER: Ahdoot R 

PROVIDER: S-EPMC11756890 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature