Real-world characteristics and outcomes of patients with multiple myeloma receiving second-line treatment in England.

ABSTRACT:

Introduction

Despite recent advances in first-line therapies for multiple myeloma (MM), most patients relapse or become refractory, underscoring the need for effective second-line (2L) regimens for relapsed/refractory MM (RRMM).

Methods

This study describes the real-world baseline characteristics, treatment patterns and clinical outcomes of adult patients diagnosed with MM between 2013 and 2020 using data collated by the National Cancer Registration and Analysis Service (NCRAS) of the National Health Service in England. The study cohorts were broadly aligned to the eligibility criteria of the ongoing DREAMM-7 (D7) and DREAMM-8 (D8) clinical trials. We focus on lenalidomide-exposed/refractory patients who received daratumumab-bortezomib-dexamethasone (DaraVd) at 2L in both co

SUBMITTER: Moore S 

PROVIDER: S-EPMC11756965 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature