Association of the nutritional risk index recorded prior to allogeneic hematopoietic cell transplantation with the clinical prognosis in children.

ABSTRACT:

Introduction

The nutritional risk index (NRI), calculated using serum albumin levels and body weight ratio is a known prognostic factor in adult hematopoietic cell transplantation (HCT). However, its usefulness in pediatric HCT settings remains unclear.

Methods

In a retrospective study, we examined pre-transplant NRI impact on outcomes in 82 pediatric patients undergoing allogeneic HCT.

Results

The 2-year non-relapse mortality (NRM) rate was 7.94% (95% confidence interval [CI], 3.05%-19.8%) and 30.8% (95% CI, 16.7%-52.2%) in the high and low NRI groups, respectively (p = 0.0037).

Conclusion

We found that poor nutritional status prior to pediatric HCT led to a worse prognosis, including increased NRM.

SUBMITTER: Yonesu H 

PROVIDER: S-EPMC11756969 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature