Clinical, immunophenotypic, and genomic findings of acute myeloid leukemia with RAM immunophenotype: Comparison with other CD56-positive acute leukemias.

ABSTRACT:

Background

Acute myeloid leukemia (AML) with RAM immunophenotype is a newly recognized high-risk AML immunophenotypic subcategory characterized by blasts with bright expression of CD56 and weak to absent expression of CD45, HLA-DR, and CD38, as first described by the Children's Oncology Group (COG). The relationship between AML-RAM and other CD56-positive acute leukemias is unclear. The goal of this study is to characterize the clinicopathological characteristics of AML with RAM phenotype and compare them with other CD56 co-expressing acute leukemias.

Methods

From a multi-institutional search, we identified a total of 160 CD56+ acute leukemia cases, including AML-RAM (n = 28), CD56+ acute undifferentiated leukemia (AUL) (n = 11), CD56+ T-lymphoblastic leukemia

SUBMITTER: Hamdan H 

PROVIDER: S-EPMC11756974 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature