Factors related to mean corpuscular volume in <i>HFE</i> p.C282Y homozygotes.

ABSTRACT:

Introduction

The aim of this study was to define the relationships between factors other than transferrin saturation (TS) to mean corpuscular volume (MCV) and macrocytosis (MCV > 100 fL) in HFE p.C282Y (rs1800562) homozygotes.

Methods

We studied white post-screening participants with p.C282Y homozygosity who did not have anemia, report cirrhosis or pregnancy, or use medications that increase MCV. We analyzed relations of MCV and macrocytosis with age, sex, diabetes reports, daily alcohol consumption, swollen or tender 2nd/3rd metacarpophalangeal (MCP) joints, TS, and serum ferritin (SF).

Results

There were 257 participants (110 men and 147 women). Median alcohol consumption, median TS, median SF, and macrocytosis prevalence were significantly greater in men. Re

SUBMITTER: Barton JC 

PROVIDER: S-EPMC11756985 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature