Association of Coprescribing of Gabapentinoid and Other Psychoactive Medications With Altered Mental Status and Falls in Adults Receiving Dialysis.

ABSTRACT:

Rationale & objective

Prescribing psychoactive medications for patients with kidney disease is common, but for patients receiving dialysis some medications may be inappropriate. We evaluated the association of coprescribing gabapentinoids and other psychoactive potentially inappropriate medications (PPIMs) (eg, sedatives or opioids) with altered mental status (AMS) and falls and whether the associations are modified by frailty.

Study design

Observational cohort study.

Setting & participants

Adults receiving dialysis represented in the US Renal Data System who had an active gabapentinoid prescription and no other PPIM prescriptions in the prior 6 months.

Exposure

PPIM coprescribing, or the presence of overlapping prescriptions of a gabapentinoid and≥1 additional

SUBMITTER: Hall RK 

PROVIDER: S-EPMC11757077 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature