A peptide mimic of SOCS1 modulates equine peripheral immune cells <i>in vitro</i> and ocular effector functions <i>in vivo</i>: implications for recurrent uveitis.

ABSTRACT:

Introduction

Recurrent uveitis (RU), an autoimmune disease, is a leading cause of ocular detriment in humans and horses. Equine and human RU share many similarities including spontaneous disease and aberrant cytokine signaling. Reduced levels of SOCS1, a critical regulator of cytokine signaling, is associated with several autoimmune diseases. Topical administration of SOCS1-KIR, a peptide mimic of SOCS1, was previously correlated to reduced ocular pathologies within ERU patients.

Methods

To further assess the translational potential of a SOCS1 mimetic to treat RU, we assessed peptide-mediated modulation of immune functions in vitro, using equine peripheral blood mononuclear cells (PBMC), and in vivo through topical administration of SOCS1-KIR into the eyes of e

SUBMITTER: Stafford LS 

PROVIDER: S-EPMC11757128 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature