Infant respiratory infections modulate lymphocyte homing to breast milk.

ABSTRACT:

Introduction

Chemokines and their receptors are essential for leukocyte migration to several tissues, including human milk. Here, we evaluated the homing of T and B lymphocyte subsets to breast milk in response to ongoing respiratory infections in the nursing infant.

Methods

Blood and mature milk were collected from healthy mothers of nurslings with respiratory infections (Group I) and from healthy mothers of healthy nurslings (Group C). Total lymphocyte, T and B cells, their subset numbers, and the expression of the homing receptors CCR5, CCR6, CCR10, and CXCR3 in these cells were evaluated in milk. Maternal serum and milk chemokine, cytokine, and IgA and IgG antibody levels were also quantified.

Results

All milk lymphocyte numbers were greater in Group I than in Gro

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC11757141 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature