Neutrophil-derived apoptotic body membranes-fused exosomes targeting treatment for myocardial infarction.

ABSTRACT: Myocardial infarction (MI) poses a substantial threat to human health, prompting extensive research into effective treatment modalities. Preclinical studies have demonstrated the therapeutic potential of mesenchymal stem cell-derived exosomes for cardiac repair. Despite their promise, the inherent limitations of natural exosomes, mainly their restricted targeting capabilities, present formidable barriers to clinical transformation. To address this, it is proposed to enhance their targeting specificity and retention in infarcted myocardium by fusing exosomes with neutrophil-derived apoptotic body membranes (NAM). These NAM inherit the surface signals from neutrophils, which allow them to home in on the damaged tissues and participate in regulating inflammatory responses. In this current wor

SUBMITTER: Wang J 

PROVIDER: S-EPMC11757162 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature