Prognosis prediction of α-FAtE score for locoregional immunotherapy in hepatocellular carcinoma.

ABSTRACT:

Purpose

The α-FAtE score, composed of alpha-fetoprotein, alkaline phosphatase, and eosinophil levels, has been reported as a predictor of prognosis in hepatocellular carcinoma (HCC) patients treated with atezolizumab plus bevacizumab. This study aimed to investigate the predictive ability of α-FAtE score for the efficacy and safety of locoregional immunotherapy as the treatment of HCC patients.

Methods and patients

We conducted a retrospective study of 446 HCC patients at Sun Yat-sen University Cancer Center from January 1^st 2019 to January 1^st 2023. The predictive performance was evaluated by the concordance index, the area under the receiver operating characteristics curve, the Kaplan-Meier curve and multiple Cox regression analysis.

Results

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SUBMITTER: Zheng Z 

PROVIDER: S-EPMC11757168 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature