Experimental adaptation to singular pathogen challenge reduces susceptibility to novel pathogens in Drosophila melanogaster.

ABSTRACT: Hosts often encounter and must respond to novel pathogens in the wild, that is pathogens that they have not encountered in recent evolutionary history, and therefore are not adapted to. How hosts respond to these novel pathogens and the outcome of such infections can be shaped by the host's evolutionary history, especially by how well adapted the host is to its native pathogens, that is pathogens they have evolved with. Host adaptation to one pathogen can either increase its susceptibility to a novel pathogen, due to specialization of immune defenses and trade-offs between different arms of the immune system, or can decrease susceptibility to novel pathogens by virtue of cross-resistance. Using laboratory Drosophila melanogaster populations, we explore if hosts experimentally adapte

SUBMITTER: Singh A 

PROVIDER: S-EPMC11757221 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature