Canine adipose-derived mesenchymal stromal cells inhibit the growth of canine hematologic malignancy cell lines.

ABSTRACT:

Introduction

Intestinal lymphoma may be latent in some dogs with chronic inflammatory enteropathy. Mesenchymal stromal cells (MSCs) have potential therapeutic applications for refractory chronic inflammatory enteropathy, but their impact on the development of potential intestinal lymphomas has not yet been evaluated. Therefore, this study was performed to investigate the effect of canine adipose-derived MSCs (cADSCs) on the growth of canine lymphoma cell lines to assess the safety of MSC-based therapy in terms of pro- and anti-tumorigenic effects.

Methods

CADSCs were co-cultured with canine lymphoma/leukemia cell lines of various lineages, with or without cell-to-cell contact, to evaluate their effects on proliferation, apoptosis, and cell cycle progression in vitro. Additio

SUBMITTER: Yasumura Y 

PROVIDER: S-EPMC11757230 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature