Mechanistic exploration of Traditional Chinese Medicine regulation on tumor immune microenvironment in the treatment of triple-negative breast cancer: based on CiteSpace and bioinformatics analysis.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer, characterized by frequent recurrence, metastasis, and poor survival outcomes despite chemotherapy-based treatments. This study aims to investigate the mechanisms by which Traditional Chinese Medicine (TCM) modulates the tumor immune microenvironment in TNBC, utilizing CiteSpace and bioinformatics analysis.

Methods

We employed CiteSpace to analyze treatment hotspots and key TCM formulations, followed by bioinformatics analysis to identify the main active components, targets, associated pathways, and their clinical implications in TNBC treatment.

Results

CiteSpace analysis highlighted key TCM formulations, including Sanhuang Decoction. Network pharmacology identified major b

SUBMITTER: Feng D 

PROVIDER: S-EPMC11757242 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature