Altered static and dynamic spontaneous brain activity in patients with dysthyroid optic neuropathy: a resting-state fMRI study.

ABSTRACT:

Purpose

To investigate static and dynamic brain functional alterations in dysthyroid optic neuropathy (DON) using resting-state functional MRI (rs-fMRI) with the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo).

Materials and methods

Fifty-seven thyroid-associated ophthalmopathy (TAO) patients (23 DON and 34 non-DON) and 27 healthy controls (HCs) underwent rs-fMRI scans. Static and dynamic ALFF (sALFF and dALFF) and ReHo (sReHo and dReHo) values were compared between groups. The support-vector machine (SVM) classification method was used to examine the diagnostic performance of the identified models.

Results

Compared to non-DON patients, DON patients showed decreased sALFF in the bilateral lingual gyrus (LING) and right cuneus (CUN), along

SUBMITTER: Lu J 

PROVIDER: S-EPMC11757300 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature